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Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice
(Elsevier Science, 2015-01)
CaV2.1 Ca2+ channels play a key role in triggering neurotransmitter release and mediating synaptic transmission. Familial hemiplegic migraine type-1 (FHM-1) is caused by missense mutations in the CACNA1A gene that encodes ...
Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons
(2010)
Abstract
Background
Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ ...
The impact of astroglial dysfunction on excitatory synaptic transmission in neuropathological conditions: the epileptic hippocampus
(Universidad de Valparaíso, 2015-08)
Astroglial cells are essential components of brain machinery. Indeed, astrocytes modulate
synaptic transmission, neuronal excitability and plasticity in healthy brain, through the Ca2+-
dependent release of neuroactive ...
Presynaptic Cav2.1 calcium channels carrying a familial hemiplegic migraine mutation r192q allow faster recovery from syanptic depression in mouse calyx of held
(American Physiological Society, 2012-12)
CaV2.1 Ca2+ channels have a dominant and specific role in initiating fast synaptic transmission at central excitatory synapses, through a close association between release sites and calcium sensors. Familial hemiplegic ...
Short-term effects of pilocarpine on rat hippocampal neurons in culture
(Blackwell Publishing Inc, 2002-01-01)
Purpose: Status epilepticus (SE) has been considered an epileptogenic factor in humans. in the pilocarpine (PILO) model, after a brief period marked by SE, the rats exhibit recurrent spontaneous seizures, mimicking the ...
A novel role for MNTB neuron dendrites in regulating action potential amplitude and cell excitability during repetitive firing
(WILEY-BLACKWELL, 2008)
Principal cells of the medial nucleus of the trapezoid body (MNTB) are simple round neurons that receive a large excitatory synapse (the calyx of Held) and many small inhibitory synapses on the soma. Strangely, these neurons ...
Glial cells modulate the synaptic transmission of NTS neurons sending projections to ventral medulla of Wistar rats
(The American Physiological Society and the Physiological Society, 2013)
There is evidence that sympathoexcitatory and respiratory responses to chemoreflex activation involve ventrolateral medulla-projecting nucleus tractus solitarius (NTS) neurons (NTS-VLM neurons) and also that ATP modulates ...
Are l-glutamate and ATP cotransmitters of the peripheral chemoreflex in the rat nucleus tractus solitarius ?
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Peripheral chemoreflex activation in awake rats or in the working heart-brainstem preparation (WHBP) produces sympathoexcitation, bradycardia and an increase in the frequency of phrenic nerve activity. Our focus is the ...
Postsynaptic recordings at afferent dendrites contacting cochlear inner hair cells: Monitoring multivesicular release at a ribbon synapse
(Journal of Visualized Experiments, 2011-02)
The afferent synapse between the inner hair cell (IHC) and the auditory nerve fiber provides an electrophysiologically accessible site for recording the postsynaptic activity of a single ribbon synapse. Ribbon synapses of ...
Modulation of acid sensing ion channel dependent protonergic neurotransmission at the mouse calyx of Held
(Pergamon-Elsevier Science Ltd, 2020-07)
Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. It has been reported that homomeric ASIC-1a channels are expressed in neurons of the medial nucleus of ...