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Genome-Wide Analysis of Copy Number Variation in Latin American Parkinson's Disease Patients
(Wiley, 2020)
Background: Parkinson's disease is the second most common neurodegenerative disorder and affects people from all ethnic backgrounds, yet little is known about the genetics of Parkinson's disease in non-European populations. ...
Chromosomal copy number variation reveals differential levels of genomic plasticity in distinct Trypanosoma cruzi strains
(BioMed Central, 2015)
Background: Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided into six discrete typing units (DTUs), named TcI-TcVI. CL Brener, the reference strain of the T. cruzi genome project, is a hybrid ...
Diversity and population-genetic properties of copy number variations and multicopy genes in cattle
(2016-06-15)
The diversity and population genetics of copy number variation (CNV) in domesticated animals are not well understood. In this study, we analysed 75 genomes of major taurine and indicine cattle breeds (including Angus, ...
Discrepancy variation of dinucleotide microsatellite repeats in eukaryotic genomes
(Sociedad de Biología de Chile, 2009)
Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas
(Nature, 2010)
BACKGROUND: Lung squamous cell carcinomas (SqCCs) occur at higher rates following arsenic exposure. Somatic DNA copy-number
alterations (CNAs) are understood to be critical drivers in several tumour types. We have assembled ...
Association study between copy number variation and beef fatty acid profile of Nellore cattle
(2018-05-01)
The aim of this study was to analyze the association between the copy number variation regions (CNVRs) and fatty acid profile phenotypes for saturated (SFA), monosaturated (MUFA), polyunsaturated (PUFA), ω6 and ω3 fatty ...
Copy Number Variation Analysis from SNP Genotyping Microarrays in Large Cohorts of Neurological Disorders
(2022)
Copy number variants (CNVs) are a major source of genetic variation in the human genome, and they are highly heterogeneous in type, size, and frequency. CNVs represent the largest portion of genomic variation
between humans, ...
Neurodevelopmental copy-number variants: A roadmap to improving outcomes by uniting patient advocates, researchers, and clinicians for collective impact
(2022)
Copy-number variants and structural variants (CNVs/SVs) drive many neurodevelopmental-related disorders. While many neurodevelopmental-related CNVs/SVs give rise to complex phenotypes, the overlap in phenotypic presentation ...