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Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design
(BioMed Central, 2013)
Background: Randomized control trials (RCTs) stopped early for benefit (truncated RCTs) are increasingly common and, on average, overestimate the relative magnitude of benefit by approximately 30%. Investigators stop trials ...
Randomized trials addressing a similar question are commonly published after a trial stopped early for benefit
(Elsevier, 2017)
Objective: We explored how investigators of ongoing or planned trials respond to the publication of a trial stopped early for benefit addressing a similar question. Study Design and Setting: We searched multiple databases ...
Experimental Studies 1st Part. Clinical Trial [Estudios experimentales 1ª parte. El ensayo clínico]
(Universidad de la Frontera, 2015)
Improving representativeness in trials: a call to action from the Global Cardiovascular Clinical Trialists Forum
(Oxford University Press, 2023)
Participants enrolled in cardiovascular disease (CVD) randomized controlled trials are not often representative of the population living with the disease. Older adults, children, women, Black, Indigenous and People of ...
Compensating control participants when the intervention is of significant value: experience in Guatemala, India, Peru and Rwanda.
(BMJ Publishing Group, 2019)
The Household Air Pollution Intervention Network (HAPIN) trial is a randomised controlled trial in Guatemala, India, Peru and Rwanda to assess the health impact of a clean cooking intervention in households using solid ...
Botanical drug clinical trial: common issues and future options
Botanical drugs are plant-derived, complex mixtures which may have synergistic effects.
In order to understand this disparity between human use and drugs approved by regulatory agencies,
we analyzed botanical drug clinical ...