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Avaliação dos efeitos de um inibidor do tipo Kunitz (Amblyomin-X) em culturas celulares de carcinoma renal
(Universidade Federal de São Paulo (UNIFESP), 2011-10-27)
The renal cell carcinoma (RCC) is currently a disease of great clinical interest. Its incidence is increasing, especially the incidental findings, which now represent 50% of new cases diagnosed. Because it is highly resistant ...
Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell
(Springer, 2016)
During the last two decades, new insights into proteasome function and its role in several human diseases made it a potential therapeutic target. In this context, Amblyomin-X is a Kunitz-type FXa inhibitor similar to ...
Avaliação Da Atividade Do Amblyomin-X Na Regulação Da Adesão E Migração De Células Endoteliais E Tumorais São Paulo,
(Universidade Federal de São Paulo (UNIFESP), 2017-02-24)
Amblyomin-X is a Kunitz-type protease inhibitor that promotes phospholipids-dependent inhibition of FXa, or inhibits the activation of FX through TF/FVlla complex. This recombinant protein shows similarity with Kunitz ...
A new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
The aim of this study was to evaluate the anti-tumor activity of Amblyomin-X, a serine protease Kunitz-type inhibitor. Amblyomin-X induced tumor mass regression and decreased number of metastatic events in a B16F10 murine ...
Efeito citotoxico do amblyomin-X em celulas tumorais de melanomase e de adenocarcinoma de pancreas
(Universidade Federal de São Paulo (UNIFESP), 2010)
Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)
Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its ...
A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production
(Springer, 2013-06-01)
In cancer-treatment, potentially therapeutic drugs trigger their effects through apoptotic mechanisms. Generally, cell response is manifested by Bcl-2 family protein regulation, the impairment of mitochondrial functions, ...
Actions of the Kunitz-type serine protease inhibitor Amblyomin-X on VEGF-A-induced angiogenesis
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012-09-01)
Amblyomin-X is a Kunitz-type serine protease inhibitor (Kunitz-type SPI) designed from the cDNA library of the Amblyomma cajennense tick, which displays in vivo anti-tumor activities. Here, the mechanisms of actions of ...