Otro
Antitubercular drug discovery: the molecular modification as promise tool
Registro en:
International Research Journal of Pharmacy and Pharmacology, v. 2, n. 1, p. 001-009, 2012.
2251-0176
9734333607975413
5737933639516944
5178218874772717
Autor
Dutra, Luiz Antonio
Melo, Thais Regina Ferreira de
Chin, Chung Man
Santos, Jean Leandro
Resumen
Tuberculosis is a chronic infectious disease caused by etiologic agent Mycobacterium tuberculosis. "It has been reported that rates of incidence is increasing and each year around 8.9-9.9 million new cases are detected”. The current TB therapy presents several problems such as long-term therapy, drug resistance, no-compliance to therapy and few therapeutic sources to treat the disease. The discovery of new drugs safer and more efficient is urgent. The molecular modification is an important tool that allows discovering new compounds that can be win these challenges. In this work, we summarize the main strategies useful to obtain a new antitubercular drug. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)