Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
Acta Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015.
Calistro Neto, José Pedro
Torres, Rômulo da Costa
Gonçalves, Giovanna Maria
Silva, Leopoldo Muniz da
Domingues, Maria Aparecida Custódio
Módolo, Norma Sueli Pinheiro
Barros, Guilherme Antonio Moreira de
To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model.