Anti dermatophytic therapy: prospects for the discovery of new drugs from natural products
Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 44, n. 4, p. 1035-1041, 2013.
Soares, Luciana Arantes
Sardi, Janaína De Cássia Orlandi
Gullo, Fernanda Patrícia
Pitangui, Nayla De Souza
Leite, Fernanda Sangalli
Mendes-Giannini, Maria José Soares
Almeida, Ana Marisa Fusco
Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments.