Otro
Cardiovascular remodeling induced by passive smoking
Registration in:
Inflammation and Allergy - Drug Targets, v. 8, n. 5, p. 334-339, 2009.
1871-5281
10.2174/187152809790031289
2-s2.0-74849118477
Author
Minicucci, Marcos Ferreira
Gaiolla, Paula Schmidt Azevedo
Paiva, Sergio Alberto Rupp de
Zornoff, Leonardo Antonio Mamede
Abstract
Coronary heart disease (CHD) is the most common cause of death in many developed countries. The major risk factors for CHD are smoking, high blood pressure, diabetes, high cholesterol levels, and lack of physical activity. Importantly, passive smoke also increases the risk for CHD. The mechanisms involved in the effects of passive smoke in CHD are complex and include endothelial dysfunction, lipoprotein modification, increased inflammation and platelet activation. Recently, several studies have shown that exposure to tobacco smoke can result in cardiac remodeling and compromised cardiac function. Potential mechanisms for these alterations are neurohumoral activation, oxidative stress, and MAPK activation. Although the vascular effects of cigarette smoke exposure are well known, the effects of tobacco smoking on the heart have received less attention. Therefore, this review will focus on the recent findings as to the effects of passive smoking in acute and chronic phases of vascular and cardiac remodeling. © 2009 Bentham Science Publishers Ltd.
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