Otro
Lichen metabolites modulate hydrogen peroxide and nitric oxide in mouse macrophages
Registro en:
Zeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 64, n. 9-10, p. 664-672, 2009.
0939-5075
WOS:000272764800010
2-s2.0-70449556478.pdf
2-s2.0-70449556478
Autor
Carlos, Iracilda Zeppone
Quilles, Marcela B.
Carli, Camila B. A.
Maia, Danielle C. G.
Benzatti, Fernanda P.
Lopes, Thiago I. B.
Gianini, Aline S.
Brum, Rosenei L.
Vilegas, Wagner
dos Santos, Lourdes C.
Honda, Neli K.
Resumen
The activities of perlatolic acid (1), atranorin (2), and lecanoric acid (3) and their derivatives, such as orsellinates and β-methyl orsellinates obtained by alcoholysis, were assessed for stimulation of the release of hydrogen peroxide and nitric oxide in cultures of peritoneal macrophage cells from mice. The hydrogen peroxide production was estimated by oxidation of phenol red, while the Griess reagent was used to determine the nitric oxide production. 1 and 4-methoxy-ethyl orsellinate (XVII) were the compounds that induced the greatest release of H 2O 2, whereas n-pentyl orsellinate (IV), iso-propyl orsellinate (V), sec-butyl orsellinate (VI), and XVII induced a small release of NO. These results indicate that lichen products and their derivatives have potential immune-modulating activities. © 2009 Verlag der Zeitschrift für Naturforschung, Tübingen.