Otro
A meniralização dental e a atividade salivar estão reduzidas em filhotes de ratas espontaneamente hipertensas (SHR)
Registro en:
Journal of Applied Oral Science, v. 14, n. 4, p. 253-259, 2006.
1678-7757
1678-7765
10.1590/S1678-77572006000400008
S1678-77572006000400008
2-s2.0-39749099661.pdf
2-s2.0-39749099661
0000-0002-8159-4853
Autor
Elias, Gracieli Prado
Santos, Otoniel Antonio Macedo Dos
Sassaki, Kikue Takebayashi
Delbem, Alberto Carlos Botazzo
Silva, Cristina Antoniali
Resumen
Several pathologies have been diagnosed in children of hypertensive mothers; however, some studies that evaluated the alterations in their oral health are not conclusive. This study analyzed the salivary gland activity and dental mineralization of offsprings of spontaneously hypertensive rats (SHR). Thirty-day-old SHR males and Wistar rats were studied. The salivary flow was evaluated by injection of pilocarpine, the protein concentration and salivary amylase activity, by the Lowry method and kinetic method at 405 nm, respectively. Enamel and dentin mineralization of the mandibular incisors was quantified with aid of the microhardness meter. The results were analyzed by the ANOVA or Student's t test (p<0.05). It was noticed that the salivary flow rate (0.026 mL/min/100 g±0.002) and salivary protein concentration (2.26mg/mL±0.14) of SHR offspring were reduced compared to Wistar normotensive offspring (0.036 mL/min/100 g±0.003 and 2.91 mg/mL±0.27, respectively), yet there was no alteration in amylase activity (SHR: 242.4 U/mL±36.9; Wistar: 163.8 U/mL±14.1). Microhardness was lower both in enamel (255.8 KHN±2.6) and dentin (59.9 KHN±0.8) for the SHR teeth compared to the Wistar teeth (enamel: 328.7 KHN±3.3 and dentin: 67.1 KHN±1.0). These results suggest that the SHR offspring are more susceptible to development of pathologies impairing oral health, once they presented lesser flow and salivary protein concentration and lower dental mineralization.