Otro
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions
Registro en:
Genetics and Molecular Biology, v. 22, n. 1, p. 25-28, 1999.
1415-4757
10.1590/S1415-47571999000100006
S1415-47571999000100006
WOS:000080079000006
2-s2.0-0032912324
Autor
Rainho, Cláudia Aparecida
Neto, José Barbieri
Correa de Moraes, Lamartine
Rogatto, Silvia Regina
Resumen
Chromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells. In addition to normal cells, we identified abnormal karyotypes with clonal numerical and structural chromosome alterations in at least two independently originated primary cultures from each lesion. Our data suggest that chromosomal aberrations can exist in vivo in non-neoplastic lesions. Other abnormalities may be due to genetic instability manifested only in vitro (culture artifacts) or may already have been present in brain tissue, reflecting previous chromosome damage (as a result of exposure to chemical treatment or enviromental clastogens). Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)