Otro
Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.
Registro en:
Planta Medica. Stuttgart: Georg Thieme Verlag, v. 62, n. 5, p. 402-404, 1996.
0032-0943
10.1055/s-2006-957925
WOS:A1996VQ03600004
Autor
Carvalho, JCT
Silva, MFC
Maciel, MAM
Pinto, Abedala Derbli
Nunes, D. S.
Lima, R. M.
Bastos, J. K.
Sarti, S. J.
Resumen
The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD(50) of t-DCTN was 555.0 mg/kg (p.o.) for mice.