Otro
Planejamento racional de fármacos baseado em produtos naturais
Registro en:
Química Nova. Sociedade Brasileira de Química, v. 24, n. 1, p. 105-111, 2001.
0100-4042
10.1590/S0100-40422001000100018
S0100-40422001000100018
S0100-40422001000100018.pdf
Autor
Montanari, Carlos Alberto
Bolzani, Vanderlan da Silva
Resumen
In the area of drug discovery, natural products represent a myriad of templates for new lead discovery. It is, however, most unlikely that the bioactive principle itself shall become a drug; it is much more likely that a medicinal chemistry project needs to be initiated as soon the potency or selectivity or specificity of the new natural product candidate has been disclosed. Brazil has an enormous biodiversity where just a few has been disclosed. Nevertheless, it urges to initiate a joint collaboration in order to circumvent a major breakdown linking between natural products and medicinal chemistry in this country. This paper is intended to encourage people to follow up one of the most pushing forward enterprise that needs to be settled: the pharmaceutical industry. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)