Otro
Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella
Registration in:
Protein Journal. New York: Springer, v. 29, n. 8, p. 567-571, 2010.
1572-3887
10.1007/s10930-010-9294-9
WOS:000284644400005
Author
Toyama, M. H.
Toyama, D. O.
Torres, V. M.
Pontes, G. C.
Farias, W. R. L.
Melo, F. R.
Oliveira, S. C. B.
Fagundes, F. H. R.
Diz Filho, E. B. S.
Cavada, B. S.
Abstract
Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)