Artículos de revistas
Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
Expessão de osteopontina e sua relação com biomarcadores prognóstico nos carcinomas mamários caninos
Fecha
2020-03-01Registro en:
Pesquisa Veterinaria Brasileira, v. 40, n. 3, p. 210-219, 2020.
1678-5150
0100-736X
10.1590/1678-5150-PVB-6489
S0100-736X2020000300210
2-s2.0-85088277890
S0100-736X2020000300210.pdf
Autor
Faculdade Multivix
Universidade Estadual Paulista (Unesp)
Universidade Federal do Espírito Santo (UFES)
Sede Popayan
Institución
Resumen
Osteopontin is a glycophosphoprotein implicated in different physiologic and pathologic processes and is known to be involved in progression and metastasis of various cancers in humans, but this relation is still little explored in the veterinary. The aim was to evaluate the expression of osteopontin in canine mammary carcinomas and its relation with well-established canine mammary tumor biomarkers. For that, expression of OPN, EGFR, HER2, and c-Kit were evaluated along with Ki67 rate in 43 mammary carcinomas. Osteopontin was demonstrated to be expressed by neoplastic epithelial cells in all carcinomas as well as in stromal cells from the tumor microenvironment. Relation between high osteopontin expression and EGFR positivity (P<0.001) and HER2 overexpression (P=0.012) was demonstrated. In conclusion, high OPN expression seems to be related to poor prognosis and MAPK pathway activation, given the association with EGFR and HER2, members of the MAPK signaling pathway.