Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas

Expessão de osteopontina e sua relação com biomarcadores prognóstico nos carcinomas mamários caninos

dc.contributorFaculdade Multivix
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal do Espírito Santo (UFES)
dc.contributorSede Popayan
dc.date.accessioned2020-12-12T02:16:01Z
dc.date.accessioned2022-12-19T21:08:35Z
dc.date.available2020-12-12T02:16:01Z
dc.date.available2022-12-19T21:08:35Z
dc.date.created2020-12-12T02:16:01Z
dc.date.issued2020-03-01
dc.identifierPesquisa Veterinaria Brasileira, v. 40, n. 3, p. 210-219, 2020.
dc.identifier1678-5150
dc.identifier0100-736X
dc.identifierhttp://hdl.handle.net/11449/200786
dc.identifier10.1590/1678-5150-PVB-6489
dc.identifierS0100-736X2020000300210
dc.identifier2-s2.0-85088277890
dc.identifierS0100-736X2020000300210.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5381420
dc.description.abstractOsteopontin is a glycophosphoprotein implicated in different physiologic and pathologic processes and is known to be involved in progression and metastasis of various cancers in humans, but this relation is still little explored in the veterinary. The aim was to evaluate the expression of osteopontin in canine mammary carcinomas and its relation with well-established canine mammary tumor biomarkers. For that, expression of OPN, EGFR, HER2, and c-Kit were evaluated along with Ki67 rate in 43 mammary carcinomas. Osteopontin was demonstrated to be expressed by neoplastic epithelial cells in all carcinomas as well as in stromal cells from the tumor microenvironment. Relation between high osteopontin expression and EGFR positivity (P<0.001) and HER2 overexpression (P=0.012) was demonstrated. In conclusion, high OPN expression seems to be related to poor prognosis and MAPK pathway activation, given the association with EGFR and HER2, members of the MAPK signaling pathway.
dc.languageeng
dc.relationPesquisa Veterinaria Brasileira
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectCancer
dc.subjectCanine mammary carcinomas
dc.subjectDogs
dc.subjectEpidermal growth factor receptor
dc.subjectHuman epidermal growth factor receptor 2
dc.subjectImmunohistochemistry
dc.subjectOsteopontin expression
dc.subjectPrognostic biomarkers
dc.titleOsteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
dc.titleExpessão de osteopontina e sua relação com biomarcadores prognóstico nos carcinomas mamários caninos
dc.typeArtículos de revistas


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