info:eu-repo/semantics/article
A new fluorescent assay for enalapril maleate
Fecha
2005-09Registro en:
Oliva, María De Los A.; Sombra, Lorena Luján; Olsina, Roberto Antonio; Masi, Adriana Noemi; A new fluorescent assay for enalapril maleate; Springer/Plenum Publishers; Journal Of Fluorescence; 15; 5; 9-2005; 723-728
1053-0509
CONICET Digital
CONICET
Autor
Oliva, María De Los A.
Sombra, Lorena Luján
Olsina, Roberto Antonio
Masi, Adriana Noemi
Resumen
A new spectrofluorimetric method for the enalapril maleate monitoring was studied. Enalapril maleate was found to be highly photolabile. This drug was evaluated according to photodegradation assay at pH 2.5 and 6. Enalapril maleate was exposed to UVA-UVB radiations. Under these specific conditions was found as degradation product, the diketopiperazine. The modification of the fluorescent properties of enalapril maleate in solution after exposure UV-radiation and the degradation mechanisms were studied. The photodegradation was followed by the developed spectrofluorimetric assay.