Artigo de Periódico
Establishing the reference range for T lymphocytes subpopulations in adults and children from Brazil
Fecha
2013Registro en:
0036-4665
v. 55, n. 5
Autor
Torres, Alex José Leite
Angelo, Ana Luiza Dias
Silva, Márcio Oliveira
Bastos, Milena de Carvalho
Souza, Denise Ferreira de
Inocêncio, Lílian Amaral
Lemos, José Alexandre Rodrigues de
S. Júnior, Ruy
Castro, Andréa Cauduro de
Martins Netto, Eduardo
Brites, Carlos
Torres, Alex José Leite
Angelo, Ana Luiza Dias
Silva, Márcio Oliveira
Bastos, Milena de Carvalho
Souza, Denise Ferreira de
Inocêncio, Lílian Amaral
Lemos, José Alexandre Rodrigues de
S. Júnior, Ruy
Castro, Andréa Cauduro de
Martins Netto, Eduardo
Brites, Carlos
Institución
Resumen
In Brazil, the existing reference values for T-lymphocytes subsets are based on data originated in other countries. There is no local information on normal variation for these parameters in Brazilian adults and children. We evaluated the normal variation found in blood donors from five large Brazilian cities, in different regions, and in children living in Salvador, and Rio de Janeiro. All samples were processed by flow cytometry. The results were analyzed according to region, gender, and lifestyle of blood donors. A total of 641 adults (63% males), and 280 children (58% males) were involved in the study. The absolute CD3+, and CD4+ cells count were significantly higher for females (adults and children). Higher CD4+ cell count in adults was associated with smoking, while higher CD8+ count was found among female children. Higher counts, for all T-cells subsets, were detected in blood donors from southeast / south regions while those living in the northern region had the lowest values. Individuals from midwestern and northeastern regions had an intermediate count for all these cells subsets. However, these differences did not reach statistical significance. In Brazil, gender and smoking, were the main determinants of differences in T-lymphocytes reference values.
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