masterThesis
Estudo termoanalítico de medicamentos de referência, genérico e similar
Fecha
2011-07-08Registro en:
MORAIS, Francisca Edivânia de. Estudo termoanalítico de medicamentos de referência, genérico e similar. 2011. 119 f. Dissertação (Mestrado em Físico-Química; Química) - Universidade Federal do Rio Grande do Norte, Natal, 2011.
Autor
Morais, Francisca Edivânia de
Resumen
This study aimed to apply, thermogravimetriy /derivative Thermogravimetriy
(TG/DTG), differential scanning calorimetry (DSC), Differential Thermal Analysis (DTA), to
conduct a comparative study on drug reference, generic and whose active principles are
similar captopril hydrochlorothiazide, ampicillin, paracetamol, aspirin and mebendazole sold
in local pharmacies. Samples of the active ingredients and dosage forms were also
characterized by absorption infrared spectroscopy (IR), X-ray diffraction (XRD) and
microscopy scanning electron (SEM). The TG / DTG curves showed a general similarity in
the thermal behavior of the samples, but also showed the influence of excipients on the
thermal stability. The DSC curve of the generic base hydrochlorothiazide showed no peak on
the fusion of the drug due to interference of lactose as a diluent, which causes interaction with
the active principle causing their degradation before the merger. The DSC curves of the drugs
consisting of paracetamol showed reproducibility at the melting point of the active and the
other thermal events. The DSC result of binary mixtures involving captopril / magnesium
stearate and mebendazole/magnesium stearate showed possible interactions or
incompatibilities evidenced by the displacement of the melting point of both drugs. The other
mixtures showed no change. The infrared spectra presented were very similar, indicating the
presence of functional groups characteristic of the constituents of the samples. The X-ray
diffraction showed peaks indicative of crystalline structure of the active ingredients as well as
some of the ingredients in the formulation of the drug and the micrographs indicate a general
heterogeneity in the size distribution of particles in the samples