Artigo
Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae
Fecha
2005-11-16Registro en:
Physiological Research, v. 54, n. 5, p. 557-564, 2005.
0862-8408
2-s2.0-27644525584
2-s2.0-27644525584.pdf
8845835550637809
4977572416129527
0000-0002-4292-3298
Autor
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
Resumen
In this study we investigated the effect of β-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 μg of glucan by i.p. route, were assayed. In vivo β-glucan administration primed spleen cells for a higher production of IL-12 and TNF-α when S. aureus was used as a stimulus. In addition, β-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for β-glucan were observed in this work. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic.
Materias
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