Diego Muñoz-Conchaa (a,b); Hermine Vogel (b);Iván Razmilic d) a. Departamento de Ciencias Agrarias, Facultad de Ciencias Agrarias y Forestales, Universidad Católica del Maule, Casilla 7D, Curicó, Chile b. Facultad de Ciencias Agrarias, Universidad de Talca, Casilla 747, Talca, Chile c. Departamento de Química, Universidad Federal de Santa Catarina, 88.040-900 Florianópolis SC, Brazil dInstituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, ChileDrimys winteri (Winteraceae) is a tree with medicinal properties native to Chile. Its bark contains polygodial and drimenol in unknown quantities, with antimicrobial and antinociceptive activity. The purpose of the present study was to quantify polygodial and drimenol concentrations in leaves of five populations of D. winteri and one of Drimys andina from different regions of Chile, by GC analysis of the hexane extract. The concentration of these compounds was also determined in the bark of one of the D. winteri populations. In dried leaves mean concentrations of 0.99% for polygodial and 0.011% for drimenol could be observed, both differing significantly among the studied populations. It is concluded that polygodial and drimenol are present in the leaves and the bark of D. winteri and in D. andina leaves, this being the first report of the presence of these compounds in the latter species