Generación de Nuevo Conocimiento: Artículos publicados en revistas especializadas - Electrónicos
Estudio cuantitativo del flujo de líquido cefalorraquídeo mediante resonancia magnética en contraste de fase: método para identificar a los pacientes con hidrocefalia a presión normal
Fecha
2014-03Autor
Forner Giner, J.
Sanz-Requena, R.
Flórez, N.
Alberich-Bayarri, A.
García-Martí, G.
Ponz, A.
Martí-Bonmat, L.
Institución
Resumen
Objectives: The aim of this study is to evaluate the use of phase-contrast MR imaging to diagnose normal pressure hydrocephalus (NPH) and differentiate it from other neurological disorders
with similar clinical symptoms.
Methods: The study included 108 subjects, of whom 61 were healthy controls and 47, patients;
in the patient group, 19 had cerebrovascular disease (CVD) and 28 had NPH. All patients underwent a phase-contrast MRI study and several CSF flow and velocity parameters were measured
at the aqueduct of Sylvius. Discriminant analyses were performed to evaluate the classification
capacity of both individual parameters and the combination of different parameters.
Results: Maximum diastolic velocity, mean flow, and stroke volume showed statistically significant differences that could be used to distinguish between NPH and CVD patients (P<.001).
Stroke volume and mean flow showed no false positive results and successful classification rates
of 86% and 79%, respectively. No other parameters or combination produced better results.
Conclusions: Phase-contrast MR imaging is a useful tool for the early diagnosis of patients with
NPH. CSF flow quantitative parameters, along with morphological features in a conventional
MR study, enable us to differentiate between NPH and CVD patients.