article
Systemic lupus erythematosus 2014.
Registro en:
ISSN: 20900422
EISSN: 2090-0430
Autor
Anaya, Juan-Manuel
Shoenfeld, Yehuda
Cervera, Ricard
Institución
Resumen
Systemic lupus erythematosus (SLE, lupus) is the prototype of systemic autoimmune disease (AD). Immune system activation in SLE is characterized by exaggerated B-cell and T-cell responses and loss of immune tolerance against self-antigens. Production and defective elimination of antibodies, circulation and tissue deposition of immune complexes, and complement and cytokine activation contribute to clinical manifestations that range from fatigue and joint pain to severe, life-threatening organ damage