Artículos de revistas
Interoception primes emotional processing: Multimodal evidence from neurodegeneration
Fecha
2021Registro en:
J. Neurosci, May 12, 2021 • 41(19):4276–4292
10.1523/JNEUROSCI.2578-20.2021
Autor
Salamone, Paula C.
Legaz, Agustina
Sedeño, Lucas
Moguilner, Sebastián
Fraile Vázquez, Matías
González Campo, Cecilia
Fittipaldi, Sol
Yoris, Adrián
Miranda, Magdalena
Birba, Agustina
Galiani, Agostina
Abrevaya, Sofía
Neely Prado, Alejandra
Martorell Caro, Miguel
Alifano, Florencia
Villagra Castro, Roque Ariel
Anunziata, Florencia
Okada de Oliveira, Maira
Pautassi, Ricardo M.
Slachevsky Chonchol, Andrea Maria
Serrano, Cecilia
García, Adolfo M.
Ibañez, Agustín
Institución
Resumen
Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of
negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and
exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive
and control-exteroceptive priming conditions followed by post-interoception and post-exteroception facial emotion recognition
(FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant
frontotemporal dementia (bvFTD), Parkinson’s disease (PD), and Alzheimer’s disease (AD). We measured online EEG modulations
of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity
patterns. Behaviorally, post-interoception negative FER was enhanced in HCs but selectively disrupted in bvFTD and
PD, with AD presenting generalized disruptions across emotion types. Only bvFTD presented impaired interoceptive accuracy.
Increased HEP modulations during post-interoception negative FER was observed in HCs and AD, but not in bvFTD or PD
patients. Across all groups, post-interoception negative FER correlated with the volume of the insula and the ACC. Also, negative
FER was associated with functional connectivity along the (a) salience network in the post-interoception condition, and
along the (b) executive network in the post-exteroception condition. These patterns were selectively disrupted in bvFTD (a)
and PD (b), respectively. Our approach underscores the multidimensional impact of interoception on emotion, while revealing
a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the
fields of nteroception, emotion, allostasis, and neurodegeneration.