Academic performance (AP) is conditioned by several factors and the self-esteem and health related to quality of life (HRQoL) are influential factors. The objective of the research was to determine the association between the nutritional levels, physical fitness, self-esteem and HRQoL with AP in adolescents. In this cross-sectional study, men (n = 219, 15.82 +/- 1.37 years) and women (n = 200, +/- 15.23 +/- 0.85 years) between 14 and 17 years of age participated. The body mass index (BMI), waist circumference (WC), height waist ratio (WtHR), physical fitness, self-esteem, HRQoL and AP were evaluated. In the comparison of the levels of self-esteem, HRQoL and AP according to the nutritional status, the schoolchildren with obesity have a lower HRQoL (P = 0.001), in the same way the self-esteem was lower in the overweight and obese schoolchildren in comparison with their normal weight peers (P = 0.013). In relation to AP, there were no differences according to nutritional status (P>0.05). The AP presented a positive relationship with physical condition, self-esteem and HRQoL (P<0.05). The adolescents with obesity had lower HRQoL than their overweight and normal weight peers, in addition AP is related to physical condition, self-esteem and HRQoL, for this reason it is important to incorporate strategies in educational establishments that improve this condition and contribute to the integral development of school children.