Artículos de revistas
The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
Fecha
2014-01-01Registro en:
Clinics. Faculdade de Medicina / USP, v. 69, n. 1, p. 28-37, 2014.
1807-5932
1980-5322
S1807-59322014000100028.pdf
S1807-59322014000100028
10.6061/clinics/2014(01)05
WOS:000331250600005
Autor
Vasconcelos, Luciano de Gois
Jackowski, Andrea Parolin
Oliveira, Maira Okada de
Flor, Yona Mayara Ribeiro
Souza, Altay Alves Lino de
Bueno, Orlando Francisco Amodeo
Brucki, Sonia Maria Dozzi
Institución
Resumen
OBJECTIVE: To establish whether alterations of brain structures in Alzheimer's disease are associated with executive dysfunction. METHODS: Nineteen patients with Alzheimer's disease and 22 older control subjects underwent a comprehensive evaluation. The clock drawing test, digit span test, executive motor function test, Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test), and Stroop test were used to evaluate executive dysfunction. A multiparametric approach using the FreeSurfer image analysis suite provided a description of volumetric and geometric features of the gray matter structures. RESULTS: The cortical thickness maps showed a negative correlation between the Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test) and the right middle frontal gyrus; a positive correlation between the executive motor function test and the left superior parietal gyrus, left middle temporal gyrus, bilateral supramarginal gyri, right middle frontal gyrus, and right precuneus; a negative correlation between the Stroop test (part III) and the right superior parietal gyrus; and a negative correlation between the Stroop test (part III) and the right middle temporal gyrus. CONCLUSION: Executive dysfunction in Alzheimer's disease is correlated with alterations not only in the frontal areas but also within many temporal and parietal regions.