Artículos de revistas
Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae)
Fecha
2012-01-01Registro en:
SANTANA, Jeferson Santos et al . Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae). Quím. Nova, São Paulo , v. 35, n. 11, p. 2245-2248, 2012
0100-4042
S0100-40422012001100029.pdf
S0100-40422012001100029
10.1590/S0100-40422012001100029
WOS:000312034600029
Autor
Santana, Jeferson Santos
Sartorelli, Patricia
Lago, Joao Henrique Ghilardi
Matsuo, Alisson Leonardo
Institución
Resumen
The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H2O and hexane, CH2Cl2, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6), being the first occurrence of 1, 4 and 6 in S. terebinthifolius.In vitro cytotoxic evaluation of 1 - 6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 - 6 were inactive.