Artículos de revistas
The Effect of Tunicamycin on the Glucose Uptake, Growth, and Cellular Adhesion in the Protozoan Parasite Crithidia fasciculata
Fecha
2014Registro en:
Rojas R, Segovia C, Trombert AN, Santander J, Manque P. The effect of tunicamycin on the glucose uptake, growth, and cellular adhesion in the protozoan parasite Crithidia fasciculata. Curr Microbiol. 2014 Oct;69(4):541-8. doi: 10.1007/s00284-014-0620-x. Epub 2014 Jun 4. PubMed PMID: 24894907.
ISSN 0717-9502
Este artículo no posee número DOI
Autor
Rojas, Robert [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]
Segovia, Christopher [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]
Trombert, Annette Nicole [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]
Santander, Javier [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]
Manque, Patricio [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]
Institución
Resumen
Crithidia fasciculata represents a very interesting model organism to study biochemical, cellular, and genetic processes unique to members of the family of the Trypanosomatidae. Thus, C. fasciculata parasitizes several species of insects and has been widely used to test new therapeutic strategies against parasitic infections. By using tunicamycin, a potent inhibitor of glycosylation in asparaginyl residues of glycoproteins (N-glycosylation), we demonstrate that N-glycosylation in C. fasciculata cells is involved in modulating glucose uptake, dramatically impacting growth, and cell adhesion. C. fasciculata treated with tunicamycin was severely affected in their ability to replicate and to adhere to polystyrene substrates and losing their ability to aggregate into small and large groups. Moreover, under tunicamycin treatment, the parasites were considerably shorter and rounder and displayed alterations in cytoplasmic vesicles formation. Furthermore, glucose uptake was significantly impaired in a tunicamycin dose-dependent manner; however, no cytotoxic effect was observed. Interestingly, this effect was reversible. Thus, when tunicamycin was removed from the culture media, the parasites recovered its growth rate, cell adhesion properties, and glucose uptake. Collectively, these results suggest that changes in the tunicamycin-dependent glycosylation levels can influence glucose uptake, cell growth, and adhesion in the protozoan parasite C. fasciculata.
Materias
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Empathy in students of specialty in physical therapy, universidad mayor in temuco, Chile [Empatía em estudiantes de kinesiología. Universidad Mayor, sede Temuco, Chile] [Empatía en estudiantes de kinesiología. Universidad Mayor, sede Temuco, Chile]
Díaz-Narváez V.P.; Salas-Alarcón D.; Bracho-Milic F.; Ocaranza-Ozímica J. (Universidad del Rosario, 2015) -
Empathy in nursing students at the universidad mayor, Temuco campus, Ix region, Chile [Empatia em estudantes de enfermagem da universidad mayor, Sede Temuco, Ix região, Chile] [Empatía en estudiantes de enfermería de la universidad mayor, Sede Temuco, Ix región, Chile]
Díaz-Narváez V.P.; Muñoz-Gámbaro G.; Duarte-Gómez N.; Reyes-Martínez M.C.; Caro S.E.; Calzadilla-Núñez A.; Alonso-Palacio L.M. (Universidad de La Sabana, 2014) -
Estudio comparativo de algunas características demográficas y epidemiológicas, de los pacientes adultos mayores desdentados totales atendidos en la clínica de prótesis totales de la Facultad de Odontología Universidad de Chile y en el Centro de Referencia Maruri durante el año 2006
Yáñez Núñez, Ruth Isabel (Universidad de Chile, 2007)Objetivo: Analizar si existen diferencias en algunas de las características Demográficas y Epidemiológicas estudiadas de los pacientes adultos mayores desdentados totales atendidos en la clínica de Prótesis Totales de ...