Artículos de revistas
Cytotoxic lignans from the stems of Styrax camporum (Styracaceae)
Fecha
2005-06-01Registro en:
Natural Product Research. Abingdon: Taylor & Francis Ltd, v. 19, n. 4, p. 319-323, 2005.
1478-6419
10.1080/14786410412331271979
WOS:000229394900003
0037579054083160
4484083685251673
4702004904231248
0000-0001-7616-9652
0000-0002-1516-7765
Autor
Universidade Estadual Paulista (Unesp)
Universidade Federal de São Paulo (UNIFESP)
Inst Bot
Institución
Resumen
An ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-) syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24 h. Activities could be observed for egonol against C6 (IC50 = 3.2 mu g/mL) and Hep-2 (IC50 = 3.6 mu g/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 mu g/mL) and HeLa (IC50 =- 5.3 mu g/mL) cells.