dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor | Inst Bot | |
dc.date.accessioned | 2014-05-20T13:24:32Z | |
dc.date.available | 2014-05-20T13:24:32Z | |
dc.date.created | 2014-05-20T13:24:32Z | |
dc.date.issued | 2005-06-01 | |
dc.identifier | Natural Product Research. Abingdon: Taylor & Francis Ltd, v. 19, n. 4, p. 319-323, 2005. | |
dc.identifier | 1478-6419 | |
dc.identifier | http://hdl.handle.net/11449/7649 | |
dc.identifier | 10.1080/14786410412331271979 | |
dc.identifier | WOS:000229394900003 | |
dc.identifier | 0037579054083160 | |
dc.identifier | 4484083685251673 | |
dc.identifier | 4702004904231248 | |
dc.identifier | 0000-0001-7616-9652 | |
dc.identifier | 0000-0002-1516-7765 | |
dc.description.abstract | An ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-) syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24 h. Activities could be observed for egonol against C6 (IC50 = 3.2 mu g/mL) and Hep-2 (IC50 = 3.6 mu g/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 mu g/mL) and HeLa (IC50 =- 5.3 mu g/mL) cells. | |
dc.language | eng | |
dc.publisher | Taylor & Francis Ltd | |
dc.relation | Natural Product Research | |
dc.relation | 1.928 | |
dc.relation | 0,671 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Styrax camporum | |
dc.subject | Styracaceae | |
dc.subject | cytotoxic lignans | |
dc.subject | MTT assay | |
dc.title | Cytotoxic lignans from the stems of Styrax camporum (Styracaceae) | |
dc.type | Artículos de revistas | |