Artículo de revista
Changes in the survival of patients with systemic lupus erythematosus in childhood: 30 Years experience in Chile
Fecha
2005Registro en:
Lupus, Volumen 14, Issue 11, 2018, Pages 918-923
09612033
10.1191/0961203303lu2183xx
Autor
González, Benito
Hernández, P.
Olguín, H.
Miranda, M.
Lira, L.
Toso, M.
Quezada, A.
Norambuena, X.
Talesnik, E.
Méndez, C.
Navarrete, C.
Institución
Resumen
The objective of this study was to analyse the survival rate and cause of death in children with systemic lupus erythematosus (SLE) during the past 30 years in Chile. A retrospective analysis was performed between 1969 and 2000 on patients attending pediatric rheumatology centres in Santiago, Chile. Survival and causes of death in 31 children followed from 1969 to 1980 fulfilling the 1982 American College of Rheumatology criteria for SLE and treated with oral steroids were compared with 50 other patients who were treated with oral steroids and an aggressive treatment of IV bolus of cyclophosphamide (38 patients) and azathioprine (12 patients). Global survival at five and 10 years follow-up for the patients studied from 1969 to 1980 was 68 and 40%, respectively. During the second study period these values were significantly improved and global survival reached 95% at five years and 90% at 10 years follow-up (P < 0.05). Survival at 10 years follow-up for patients with lupus nephropathy i