Artículos de revistas
Genomic predictions and genome-wide association study of resistance against Piscirickettsia salmonis in coho salmon (Oncorhynchus kisutch) using ddRAD sequencing
Fecha
2018Registro en:
G3: Genes, Genomes, Genetics, Volumen 8, Issue 4, 2018, Pages 1183-1194
21601836
10.1534/g3.118.200053
Autor
Barría, Agustín
Christensen, Kris A.
Yoshida, Grazyella M.
Correa, Katharina
Jedlicki, Ana
Lhorente, Jean P.
Davidson, William S.
Yáñez, José M.
Institución
Resumen
© 2018 Peccoud et al. Piscirickettsia salmonis is one of the main infectious diseases affecting coho salmon (Oncorhynchus kisutch) farming, and current treatments have been ineffective for the control of this disease. Genetic improvement for P. salmonis resistance has been proposed as a feasible alternative for the control of this infectious disease in farmed fish. Genotyping by sequencing (GBS) strategies allow genotyping of hundreds of individuals with thousands of single nucleotide polymorphisms (SNPs), which can be used to perform genome wide association studies (GWAS) and predict genetic values using genome-wide information. We used double-digest restriction-site associated DNA (ddRAD) sequencing to dissect the genetic architecture of resistance against P. salmonis in a farmed coho salmon population and to identify molecular markers associated with the trait. We also evaluated genomic selection (GS) models in order to determine the potential to accelerate the genetic improvement o