Artículos de revistas
The oleic acid esterification of policosanol increases its bioavailability and hypocholesterolemic action in rats
Fecha
2012-10Registro en:
Grasas y Aceites, 63 (4), octubre-diciembre, 345-354, 2012 doi: 10.3989/gya.010612
0017-3495
Autor
Haim, D.
Valenzuela, A.
Brañes, M. C.
Fuenzalida, M.
Videla Cabrera, Luis
Institución
Resumen
Policosanol comprises a mixture of long-chain aliphatic
alcohols from sugarcane wax. More than 50 studies indicate
that policosanol decreases serum cholesterol, while others
failed to reproduce this effect. The objective of this investigation
was to assess the bioavailability of esterified policosanol
and non-esterified policosanol (NEP), in relation to their
hypocholesterolemic effects. Sprague Dawley rats were given
a daily oral dose of 100 mg/kg of NEP, 117 mg kg–1 of butyric
acid esterified policosanol (BAEP), or 164 mg kg–1 of oleic acid
esterified policosanol (OAEP). Policosanol absorption was
evaluated in plasma between 0 and 3 hours after ingestion. To
assess changes in total cholesterol, LDL-cholesterol, HDLcholesterol
and triacylglycerols in plasma and liver 3-hydroxy-
3-methylglutaryl coenzyme A reductase (HMG- CoA red)
phosphorylation, the rats were supplemented with nonesterified
or esterified policosanol for 5 weeks. The results
indicate that policosanol absorption was significantly greater in
OAEP-treated rats than in those subjected to NEP or BAEP
administration. OAEP significantly reduced plasma total and
LDL-cholesterol in rats, in addition to a 5.6-fold increase
(P < 0.05) in the hepatic content of phosphorylated HMG-CoA
red over the control values. In conclusion, esterification of
policosanol with oleic acid enhances policosanol bioavailability,
and significantly improves the serum lipid profile in
normocholesterolemic rats in association with the inactivation
of HMG-CoA red controlling cholesterogenesis