Artículos de revistas
The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line
Fecha
2009-11-30Registro en:
BMC DEVELOPMENTAL BIOLOGY, Volume: 9, Article Number: 58, 2009
1471-213X
Autor
Pistocchi, Anna
Feijóo, Carmen
Cabrera Pérez, Pablo
Villablanca, Eduardo
Allende Connelly, Miguel
Cotelli, Franco
Institución
Resumen
Background: The lateral line system in zebrafish is composed of a series of organs called
neuromasts, which are distributed over the body surface. Neuromasts contain clusters of hair cells,
surrounded by accessory cells.
Results: In this report we describe zebrafish prox1 mRNA expression in the migrating primordium
and in the neuromasts of the posterior lateral line. Furthermore, using an antibody against Prox1
we characterize expression of the protein in different cell types within neuromasts, and we show
distribution among the supporting cells and hair cells.
Conclusion: Functional analysis using antisense morpholinos indicates that prox1 activity is crucial
for the hair cells to differentiate properly and acquire functionality, while having no role in
development of other cell types in neuromasts.