Artículos de revistas
Phytotoxic Withanolides from Jaborosa rotacea
Fecha
2006-04-05Registro en:
Oberti, Juan Carlos María; Nicotra, Viviana Estela; Burton, Gerardo; Garland, María Teresa; Baggio, Ricardo F.; Guerrero, Cecilia; et al.; Phytotoxic Withanolides from Jaborosa rotacea; American Chemical Society; Journal of Natural Products; 69; 5; 5-4-2006; 783-789
0163-3864
CONICET Digital
CONICET
Autor
Nicotra, Viviana Estela
Ramacciotti, Natalia S.
Gil, Roberto R.
Oberti, Juan Carlos María
Feresin, Gabriela Egly
Guerrero, Cecilia
Baggio, Ricardo F.
Garland, María Teresa
Burton, Gerardo
Resumen
Twelve new withanolides were isolated from the aerial part of Jaborosa rotacea: five had a spiranoid δ-lactone (1-5); one contained a 26,12-δ-lactone and a C-12-C-23 bond (6); five corresponded to trechonolide-type withanolides with configuration at C-23 opposite of those previously isolated (7, 8, 10-12); two of these have an additional oxido-bridge between C-21 and C-24; finally a withanolide with a hemiketal ring formed between a 21-hydroxyl and a 12-ketone (13) and the closely related jaborosalactone R were also isolated. New compounds were fully characterized by a combination of spectroscopic methods (1D and 2D NMR and MS). The structures of the spiranoid withanolide and of the epimer of trechonolide A were confirmed by X-ray diffraction studies. Compounds 4, 5, 6, and 8 showed selective phytotoxicity toward monocotyledoneous and dicotyledoneous species.