Artículos de revistas
Combined effects of transferrin and thyroid hormone during oligodendrogenesis In vitro
Fecha
2016-07Registro en:
Marziali, Leandro Nazareno; Correale, Jorge; Garcia, Corina Ileana; Pasquini, Juana Maria; Combined effects of transferrin and thyroid hormone during oligodendrogenesis In vitro; Wiley; Glia; 64; 11; 7-2016; 1879-1891
1098-1136
CONICET Digital
CONICET
Autor
Marziali, Leandro Nazareno
Correale, Jorge
Garcia, Corina Ileana
Pasquini, Juana Maria
Resumen
Thyroid hormones (THs) and transferrin (Tf) are factors capable of favoring myelination due to their positive effects on oligodendroglial cell (OLG) differentiation. The first notion of a combined effect of apotransferrin (aTf) and TH emerged from experiments conducted in young hyperthyroid animals, which showed a seven-fold increase in the expression of Tf mRNA and precocious myelination when compared with control animals. The mechanism underlying this phenomenon in young hyperthyroid rats could consist of an increase in Tf synthesis, which in the CNS is almost exclusively produced by OLG. Overall, our results show that, during the initial stages of OLG differentiation, Tf synthesis triggers thyroid hormone receptor alpha 1 (TRα1) expression in the subventricular zone (SVZ) and promotes proliferating cells to become responsive to this trophic factor. Exposure to TH could then regulate Tf expression through TRα1 and promote the induction of thyroid hormone receptor beta (TRβ) expression, which mediates TH effects on myelination through the activation of final OLG differentiation. This regulation of the combined effects of Tf and THs implies that both factors are fundamental actors during oligodendrogenesis.