Artículos de revistas
Effects of hydroxy-xanthones on dipalmitoylphosphatidylcholine lipid bilayers: A theoretical and experimental study
Fecha
2017-08Registro en:
Sierra, Maria Belen; Alarcon, Laureano Martin; Gerbino, Darío César; Pedroni, Viviana Isabel; Buffo, Flavia Edith; et al.; Effects of hydroxy-xanthones on dipalmitoylphosphatidylcholine lipid bilayers: A theoretical and experimental study; Elsevier Ireland; Chemistry And Physics Of Lipids; 206; 8-2017; 1-8
0009-3084
CONICET Digital
CONICET
Autor
Sierra, Maria Belen
Alarcon, Laureano Martin
Gerbino, Darío César
Pedroni, Viviana Isabel
Buffo, Flavia Edith
Morini, Marcela Ana
Resumen
Xanthones and derivatives are natural active compounds whose interest has been increased due to its several pharmacological effects. In this work, effects of hydroxy-xanthones on the physicochemical properties of dipalmitoylphosphatidylcholine (DPPC) liposomes have been investigated in terms of lipid bilayer fluidity, by means of molecular dynamics simulations and temperature dependence of zeta potential studies. Experimental results predict, in good agreement with simulations, that xanthones are able to be incorporated into DPPC liposomes with certain localization, fluidizing the bilayer. Both effects, localization and fluidity were found to be dependent of the number of hydroxilic substituents of the xanthone and the lipid phase state.