Artículos de revistas
Predictive value of galectin-1 in the development and progression of HIV-associated lymphoma
Vase, MajaØlholm; Ludvigsen, Maja; Bendix, Knud; Dutoit, Stephen H.; Hjortebjerg, Rikke; et al.; Predictive value of galectin-1 in the development and progression of HIV-associated lymphoma; Lippincott Williams; Aids; 31; 16; 23-10-2017; 2311-2313
Dutoit, Stephen H.
Møller, Michael B.
Denton, Paul W.
Rabinovich, Gabriel Adrián
Larsen, Carsten S.
At AHIV-1 infection, the binding of the viral envelopeproteins to CD4þ is essential for viral transmission, andthis process is facilitated by interaction with the highlyconserved host lectin, galectin-1 (Gal-1) [1?3]. Withinthe tumor microenvironment, Gal-1 is expressed by bothtumor and stromal cells where it promotes tumorimmune escape and favors hypoxia-driven angiogenesis[4?6]. In sporadically occurring Hodgkin lymphoma,high Gal-1 expression at diagnosis is associated withpoorer treatment response , and high soluble Gal-1(sGal-1) correlates with adverse disease characteristics .Previous studies have shown that targeted inhibition ofGal-1 prevents tumor-induced immunosuppression[9,10] as well as inhibits tumor growth and metastasisin various tumor models [6,11?13].In conclusion, the results of our study indicate that Gal-1 is significantly associated with risk of lymphoma in HIV-infected individuals and may represent an attractive futuretarget for the management of HIV-associated lymphoma.