Artículos de revistas
Nicotine modulates the long-lasting storage of fear memory
Fecha
2013-02Registro en:
Lima, Ramón H.; Radiske, Andressa; Köhler, Cristiano A.; González, María Carolina; Rossato, Janine Inez; et al.; Nicotine modulates the long-lasting storage of fear memory; Cold Spring Harbor Lab Press; Learning & Memory (cold Spring Harbor, N.y.); 20; 3; 2-2013; 120-124
1072-0502
1549-5485
Autor
Lima, Ramón H.
Radiske, Andressa
Köhler, Cristiano A.
González, María Carolina
Rossato, Janine Inez
Bevilaqua, Lia R.
Medina, Jorge Horacio
Cammarota, Martin Pablo
Resumen
Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA–hippocampus dopamine connections.