Actas de congresos
Longitudinal Characterization Of Lymphocytes Obtained From Pregnacies As Low Or High Risk Of Preeclampsia
Fecha
2016Institución
Resumen
series of anatomical, metabolic, endocrine, and immunological changes that occur during
gestation. In a normal pregnancy, there is an immune-tolerant environment preventing fetal
rejection. Early alterations during the first trimester of pregnancy in the Th1/Th17 (proinflammatory)
v/s Th2 profiles and NK cells may be associated with pathological
conditions such as preeclampsia. Preeclampsia is characterized by hypertension, proteinuria
and an exacerbated immune system activation in response to altered spiral arteries
remodeling due to partial extra-villous trophoblast invasion, which can be assessed noninvasively
by uterine artery Doppler throughout pregnancy. The aim of this study was to
characterize longitudinally the immune pattern of normal pregnancies according to noninvasive
uterine artery assessment.
Material and Methods: We measured the expression of inflammatory cytokines in T cells
and regulatory and peripheral NK cells from PBMCs obtained from pregnant women at 12
weeks of gestation using flow cytometry. These pregnancies were sub-classified according
to uterine artery Doppler assessment as “high-risk” or “low-risk” for developing
preeclampsia.
Results: A sub-group of pregnancies showed an increased level of IFN-g and IL-4
producing T cells and increased level of Regulatory NK cells which appears to be
associated with uterine artery resistance at the time of sampling.
Discussion: These findings might contribute to a better understanding of the role of T cells
in normal and pathological pregnancies