Artículos de revistas
Eye enucleation activates the transcription nuclear factor kappa-B in the rat superior colliculus
Fecha
2012Registro en:
NEUROSCIENCE LETTERS, CLARE, v. 521, n. 2, pp. 104-108, 2012
0304-3940
10.1016/j.neulet.2012.05.051
Autor
Hernandes, Marina S.
Lima, Larissa S.
Scavone, Cristoforo
Lopes, Lucia R.
Britto, Luiz R. G.
Institución
Resumen
Ocular enucleation produces significant morphological and physiological changes in central visual areas. However, our knowledge of the molecular events resulting from eye enucleation in visual brain areas remains elusive. We characterized here the transcription nuclear factor kappa-B (NF-kappa B) activation induced by ocular enucleation in the rat superior colliculus (SC). We also tested the effectiveness of the synthetic glucocorticoid dexamethasone in inhibiting its activation. Electrophoretic mobility shift assays to detect NF-kappa B indicated that this transcription factor is activated in the SC from 1 h to day 15 postlesion. The expression of p65 and p50 proteins in the nuclear extracts was also increased. Dexamethasone treatment was able to significantly inhibit NF-kappa B activation. These findings suggest that this transcriptional factor is importantly involved in the visual system short-term processes that ensue after retinal lesions in the adult brain. (C) 2012 Elsevier Ireland Ltd. All rights reserved.