Artículos de revistas
Hyperinsulinemic hypoglycemia of the infancy. Analysis of clinical data from a Brazilian sample
Fecha
2012-12Registro en:
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, RIO DE JANEIRO, RJ, v. 56, pp. 666-671, DEC, 2012
0004-2730
10.1590/S0004-27302012000900011
Autor
Liberatore Junior, Raphael Del Roio
Negri, Alcinda Aranha
Martinelli Junior, Carlos Eduardo
Kochi, Cristiane
Silva, Ivani Novato
Collett-Solberg, Paulo Ferrez
Institución
Resumen
Objective: To review the presentation of hyperinsulinemic hypoglycemia of the infancy (HHI), its treatment and histology in Brazilian pediatric endocrinology sections. Materials and method: The protocol analyzed data of birth, laboratory results, treatment, surgery, and pancreas histology. Results: Twenty-five cases of HHI from six centers were analyzed: 15 male, 3/25 born by vaginal delivery. The average age at diagnosis was 10.3 days. Glucose and insulin levels in the critical sample showed an average of 24.7 mg/dL and 26.3 UI/dL. Intravenous infusion of the glucose was greater than 10 mg/kg/min in all cases (M:19,1). Diazoxide was used in 15/25 of the cases, octreotide in 10, glucocorticoid in 8, growth hormone in 3, nifedipine in 2 and glucagon in 1. Ten of the cases underwent pancreatectomy and histology results showed the diffuse form of disease. Conclusion: This is the first critic review of a Brazilian sample with congenital HHI. Arq Bras Endocrinol Metab. 2012; 56(9): 666-71