Artículos de revistas
Reduction of acethylcolinesterase activity in the brain of mdx mice
Fecha
2011Registro en:
NEUROMUSCULAR DISORDERS, v.21, n.5, p.359-362, 2011
0960-8966
10.1016/j.nmd.2011.02.017
Autor
COMIM, Clarissa M.
MORAZ, Thais
ABREU, Igor
FRAGA, Daiane B.
GHEDIM, Fernando V.
MILDNER, Natalia
TUON, Lisiane
VAINZOF, Mariz
ZUGNO, Alexandra I.
QUEVEDO, Joao
Institución
Resumen
Lack of dystrophin in brain structures have been involved with impaired cognitive functions. Acethylcolinesterase (AChE) is implicated in many cognitive functions and probably plays important roles in neurodegenerative disorders. In the present study, we investigated AChE activity in the prefrontal cortex, hippocampus, striatum and cortex of mdx mice. To this aim, brain tissues from male dystrophic mdx and normal control mice were used. We observed that mdx mice display a reduction in AChE activity of 40-60% in all brain structures evaluated. In conclusion, dystrophin deficiency may be affecting AChE activity and contributing negatively, in part, to memory storage and restoring. (C) 2011 Elsevier B.V. All rights reserved.