Artículos de revistas
MITOCHONDRIAL RESPIRATORY CHAIN AND CREATINE KINASE ACTIVITIES IN mdx MOUSE BRAIN
Date
2010Registration in:
MUSCLE & NERVE, v.41, n.2, p.257-260, 2010
0148-639X
10.1002/mus.21559
Author
TUON, Lisiane
COMIM, Clarissa M.
FRAGA, Daine B.
SCAINI, Giselli
REZIN, Gislaine T.
BAPTISTA, Bruna R.
STRECK, Emilio L.
VAINZOF, Mariz
QUEVEDO, Joao
Institutions
Abstract
In this study we investigated energy metabolism in the mdx mouse brain. To this end, prefrontal cortex, cerebellum, hippocampus, striatum, and cortex were analyzed. There was a decrease in Complex I but not in Complex 11 activity in all structures. There was an increase in Complex III activity in striatum and a decrease in Complex IV activity in prefrontal cortex and striatum. Mitochondrial creatine kinase activity was increased in hippocampus, prefrontal cortex, cortex, and striatum. Our results indicate that there is energy metabolism dysfunction in the mdx mouse brain. Muscle Nerve 41: 257-260, 2010