Artículos de revistas
Degree of endothelium injury promotes fibroelastogenesis in experimental acute lung injury
Fecha
2010Registro en:
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, v.173, n.2, p.179-188, 2010
1569-9048
10.1016/j.resp.2010.08.005
Autor
CHAO, Monica C. M.
GARCIA, Cristiane S. N. B.
OLIVEIRA, Mariana B. G. de
SANTOS, Raquel S.
LUCAS, Isabela H.
SILVA, Pedro L.
VIEIRA-ABREU, Adriana
CASTRO-FARIA-NETO, Hugo C. de
PARRA-CUENTAS, Edwin R.
CAPELOZZI, Vera L.
PELOSI, Paolo
ROCCO, Patricia R. M.
Institución
Resumen
We tested the hypothesis that at the early phase of acute lung injury (ALI) the degree of endothelium injury may predict lung parenchyma remodelling For this purpose, two models of extrapulmonary ALI induced by Escherichia col: lipopolysaccharide (ALI-LPS) or cecal ligation and puncture (ALI-CLP) were developed in mice At day 1, these models had similar degrees of lung mechanical compromise, epithelial damage, and intraperitoneal inflammation, but endothelial lesion was greater in ALI-CLP A time course analysis revealed, at day 7 ALI-CLP had higher degrees of epithelial lesion, denudation of basement membrane, endothelial damage, elastic and collagen fibre content, neutrophils in bronchoalveolar lavage fluid (BALF), peritoneal fluid and blood, levels of interleukin-6, KC (murine analogue of IL-8), and transforming growth factor-beta in BALF Conversely, the number of lung apoptotic cells was similar in both groups In conclusion, the intensity of fibroelastogenesis was affected by endothelium injury in addition to the maintenance of epithelial damage and intraperitoneal inflammation. (C) 2010 Elsevier B V All rights reserved