Artículos de revistas
Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis
Fecha
2009Registro en:
CLINICAL AND VACCINE IMMUNOLOGY, v.16, n.6, p.953-955, 2009
1556-6811
10.1128/CVI.00071-09
Autor
CACERE, Camila R.
MENDES-GIANNINI, Maria J. S.
VALLE, Antonio Carlos F. do
DUARTE, Alberto J. S.
BENARD, Gil
Institución
Resumen
To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.