Artículos de revistas
Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico
Fecha
2010Registro en:
Química Nova, v.33, n.1, p.159-171, 2010
0100-4042
10.1590/S0100-40422010000100029
Autor
CUNHA, Vanessa R. R.
FERREIRA, Ana Maria da C.
CONSTANTINO, Vera R. L.
TRONTO, Jairo
VALIM, João B.
Institución
Resumen
Studies about the inorganic nanoparticles applying for non-viral release of biological and therapeutic species have been intensified nowadays. This work reviews the preparation strategies and application of layered double hydroxides (LDH) as carriers for storing, carrying and control delivery of intercalated species as drugs and DNA for gene therapy. LDH show low toxicity, biocompatibility, high anion exchange capacity, surface sites for functionalization, and a suitable equilibrium between chemical stability and biodegradability. LDH can increase the intercalated species stability and promote its sub-cellular uptake for biomedical purposes. Concerning the healthy field, LDH have been evaluated for clinical diagnosis as a biosensor component.