Actas de congresos
Incorporation And Release Kinetics Of Alpha-bisabolol From Pcl And Chitosan/guar Gum Membranes
Brasilian Journal Of Chemical Engineering. Brazilian Soc Chemical Eng , v. 33, p. 453 - 467, 2016.
Bombaldi de Souza
F. C.; Bombaldi de Souza
R. F.; Moraes
Alpha-bisabolol, an anti-inflammatory and antioxidant compound extracted from candeia trees (Eremanthus erythropappus), was incorporated into hydrophobic polycaprolactone (PCL) and hydrophilic chitosan/guar gum (Ch-G) membranes aiming at the production of bioactive wound dressings. The incorporation efficiency achieved a maximum of ca. 18% (1 gram of alpha-bisabolol per gram of membrane) for Ch-G membranes. For PCL membranes, all of the active compound added was retained (0.2 gram of alpha-bisabolol per gram of membrane). Alpha-bisabolol release in phosphate-buffered saline was relatively slow in both cases, reaching around 6% and 24% after 120 hours respectively for PCL and Ch-G membranes presenting equivalent initial alpha-bisabolol/membrane mass ratios. Both formulations were capable of releasing alpha-bisabolol in the typically recommended topical dose range (from 1 to 10 grams of alpha-bisabolol per gram of vehicle). The extended release periods observed are advantageous, allowing less frequent dressing changes and contributing to turn the treatment more comfortable for the patient.33345346720th Brazilian Congress of Chemical Engineering (COBEQ)OCT 19-22, 2014Florianopolis, BRAZIL