Artículos de revistas
Sers Hyperspectral Imaging Assisted By Mcr-als For Studying Polymeric Microfilms Loaded With Paracetamol
Registro en:
Sers Hyperspectral Imaging Assisted By Mcr-als For Studying Polymeric Microfilms Loaded With Paracetamol. Elsevier Science Bv, v. 123, p. 243-251 NOV-2015.
0026-265X
WOS:000360512100034
10.1016/j.microc.2015.07.003
Autor
Mamian-Lopez
Monica B.; Poppi
Ronei J.
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) In this study, a combination of the high detectability and specificity of the SERS technique with powerful chemometric tools was used to obtain hyperspectral images in order to assess the chemical distribution of the components of polymeric microfilms loaded with paracetamol as active principle. Four microfilms with drug content ranging between 5.42 and 18.62% were fabricated directly over nanostructured gold substrates and spectra were acquired over an area of 4 x 4 mm. Chemical images were first built following a qualitative approach by applying principal component analysis (PCA) and calculating correlation coefficients. With the algorithm multivarlate curve resolution-alternating least squares (MCR-ALS), the mean concentrations of all components were calculated with relative error values between 3.5 and 4.9% for paracetaniol. With the proposed methodology, both qualitative and quantitative assessments of the distribution of constituents of polymeric microfilms were successfully performed. In addition, physical-chemistry interactions among them could be also analyzed. (C) 2015 Elsevier B.V. All rights reserved. 123
243 251 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) FAPESP [process Fapesp: 08/57805-2, CNPq: 573672/2008-3] CAPES [process 33003017007P0]