Artículos de revistas
Il10 Inversely Correlates With The Percentage Of Cd8⁺ Cells In Mds Patients.
Registro en:
Leukemia Research. v. 37, n. 5, p. 541-6, 2013-May.
1873-5835
10.1016/j.leukres.2013.01.019
23453286
Autor
Lopes, Matheus Rodrigues
Traina, Fabiola
Campos, Paula de Melo
Pereira, João Kleber Novais
Machado-Neto, João Agostinho
Machado, Helymar da Costa
Gilli, Simone Cristina Olenscki
Saad, Sara Teresinha Olalla
Favaro, Patricia
Institución
Resumen
The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. 37 541-6